ZEJULA (niraparib) Dosing and Adverse Reaction Management

EXPLORE DOSING FOR ZEJULA IN PATIENTS WITH OVARIAN CANCER
IN THE FOLLOWING TREATMENT SETTINGS:

ZEJULA: Convenient
once-daily oral dosing1

Once-Daily
Oral Monotherapy

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Taken With
or Without Food

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Taken Any Time
of the Day

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Bedtime administration may be a potential method for managing nausea

ZEJULA should be taken at approximately the same time each day1

Drug-Drug
Interactions

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No specific drug-drug interactions have been reported with ZEJULA

No clinical drug interaction studies have been performed with ZEJULA.

Once-daily oral dosing and appropriate dose modification
support long-term treatment with ZEJULA1

Recommended ZEJULA starting dose by indication1

ZEJULA (niraparib) recommended starting dose by indication
ZEJULA (niraparib) recommended starting dose by indication

For patients with moderate hepatic impairment, reduce the starting dosage of ZEJULA to 200 mg once daily. Monitor patients for hematologic toxicity and reduce the dose further, if needed.1